Tyrosine phosphorylation of NO-sensitive guanylyl cyclase
نویسندگان
چکیده
منابع مشابه
Reactive oxygen species induce tyrosine phosphorylation of and Src kinase recruitment to NO-sensitive guanylyl cyclase.
Soluble guanylyl cyclase (sGC) is the major cytosolic receptor for nitric oxide (NO) that converts GTP into the second messenger cGMP in a NO-dependent manner. Other factors controlling this key enzyme are intracellular proteins such as Hsp90 and PSD95, which bind to sGC and modulate its activity, stability, and localization. To date little is known about the effects of posttranslational modifi...
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Background The NO/cGMP signal transduction is involved in the regulation of a variety of physiological processes e.g. smooth muscle relaxation, inhibition of platelet aggregation and synaptic plasticity. Nitric oxide (NO) is produced by NO synthases and acts mainly on NOsensitive guanylyl cyclase (NO-GC), the most important NO receptor. NO stimulation of NO-GC leads to production of the second ...
متن کاملNO activation of guanylyl cyclase.
Nitric oxide (NO)-sensitive guanylyl-cyclase (GC) is the most important receptor for the signaling molecule NO. Activation of the enzyme is brought about by binding of NO to the prosthetic heme group. By monitoring NO-binding and catalytic activity simultaneously, we show that NO activates GC only if the reaction products of the enzyme are present. NO-binding in the absence of the products did ...
متن کاملRegulation of soluble guanylyl cyclase by phosphorylation
Results In vitro kinase assays revealed that the α1, but not the β1, subunit of sGC is a PKG substrate and that the phosphorylation site is located within the first 360 residues of the α1. A constitutively active form of PKG stimulated incorporation of 32P into the α1 subunit in vivo. In addition, PKG could be detected in sGC immunoprecipitates, suggesting that the two proteins interact in cell...
متن کاملNO-sensitive guanylyl cyclase and NO-induced feedback inhibition in cGMP signaling.
Most effects of the signaling molecule nitric oxide (NO) are mediated by the stimulation of NO-sensitive guanylyl cyclase (GC) and the subsequent intracellular increase in cGMP. Two isoforms of NO-sensitive GC have been identified to date that share regulatory properties but differ in their subcellular localization; the more ubiquitously expressed alpha1beta1 heterodimer, and the alpha2beta1 is...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2005
ISSN: 1471-2210
DOI: 10.1186/1471-2210-5-s1-p39